Trifluoroacetic acid|TFA
1. Molecular Formula: C2HF3O2
2. Molecular Weight: 114.02
3. CAS NO.: 76-05-1
4. Purity：Min 99.5%
Description
| Index | Standard |
|---|---|
| Appearance | Colorless liquid |
| Purity | ≥99% (by GC) |
Properties:
Trifluoroacetic acid (TFA) is a strong carboxylic acid with high acidity due to the electron-withdrawing effect of the trifluoromethyl group. It is highly soluble in water and most organic solvents (e.g., ethanol, ether, dichloromethane). It is corrosive and hygroscopic, requiring careful handling.
Application:
- Pharmaceuticals: Widely used as a solvent and reagent in peptide synthesis, drug intermediates, and protecting group removal.
- Organic Synthesis: Effective catalyst and solvent for esterifications, acylations, and other reactions.
- Chemical Industry: Used in the production of dyes, agrochemicals, and specialty chemicals.
- Analytical Chemistry: Mobile phase modifier in HPLC for improved separation.
Package and Storage:
- Package: 25 kg/drum, 250 kg/drum, or customized packaging.
- Storage: Store in a tightly sealed container in a cool, dry, well-ventilated area. Avoid contact with moisture and incompatible materials (e.g., strong bases, oxidizers). Keep away from light.
