Ingredient Spotlight｜Bio-Based Succinic Acid: From TCA Cycle to Skincare Hero
With a tiny molecular weight of 118.09 and two carboxyl groups, this small molecule packs a big punch—deep penetration, anti-acne, oil control, and gentle exfoliation all come naturally. Compared to azelaic acid? Succinic acid wins in almost every way. Why? Structure determines function.
Clinically Backed Results – Without the Sting
Though still a newcomer in mainstream skincare, succinic acid is making waves in aesthetic dermatology.
Take the Swiss medical beauty brand Hyalual Xela Rederm, known for its post-procedure skin recovery line. Instead of topical creams, their succinic acid product is used in mesotherapy injections.
In a clinical study involving 80 patients aged 18–46 with various degrees of acne scars:
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92.5% showed visible improvement after just 1 month of microneedling with sodium hyaluronate + sodium succinate
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7.5% had no noticeable change
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2.5% reported only mild improvement
As always, no method is 100% effective, and any visible change—however small—was considered “effective” by clinicians.
Succinic Acid vs Salicylic Acid: The Gentle Giant
In terms of antibacterial activity against Cutibacterium acnes (ATCC11827), succinic acid is nearly equivalent to salicylic acid at the same concentration. But here’s the game changer: it’s far more gentle.
In a clinical test with 60 Asian volunteers with oily, blemished skin, subjects applied:
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A placebo cream
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A 2% salicylic acid cream
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A 2% succinic acid cream
Twice daily for 28 days. The results?
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Succinic acid significantly outperformed salicylic acid in improving skin radiance and oil balance
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Skin tolerated succinic acid in as little as 2 days
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No dramatic pH drop, making it suitable for sensitive skin
From a formulation standpoint, succinic acid is also far easier to work with—stable, pH-friendly, and compatible with a wide range of emulsions.
A Bio-Based Ingredient for a Sustainable Future
Unlike petrochemical-derived acids, succinic acid can be obtained from renewable resources such as glucose or corn starch through microbial fermentation—qualifying it as a bio-based, biodegradable material.
Already used in the production of biodegradable plastics like PBS, and in various pharmaceutical and agricultural fields, succinic acid is now carving out a place in cosmetic science as both a functional and sustainable active ingredient.
Ideal Applications for Succinic Acid in Skincare
| Product Type | Functional Benefits |
|---|---|
| Acne Serums & Creams | Antibacterial, anti-inflammatory, gentle exfoliant |
| Oily Skin Balancing Lotions | Oil control, pore-clearing |
| Sensitive Skin Solutions | pH-friendly, barrier-friendly |
| Post-Aesthetic Recovery | Soothing, scar prevention, pigment regulation |
Summary: Small Molecule, Big Potential
Succinic acid’s journey from a humble TCA cycle intermediate to a next-gen skincare active reflects a larger trend in clean beauty and dermocosmetics.
Thanks to its natural origin, mildness, and scientifically backed benefits, bio-based succinic acid is poised to become a go-to solution for formulators, dermatologists, and eco-conscious consumers alike.
Interested in formulation ideas, technical specs, or sample access?
Reach out to explore how this “metabolic star” can elevate your product line.
Disclaimer: The viewpoints and data presented in this article are sourced from online content and public studies, and are intended for reference and discussion purposes only.
