130336-16-2 | 3′,5′-Dichloro-2,2,2-trifluoroacetophenone| Versatile Fluorinated Building Block
Introduction
3′,5′-Dichloro-2,2,2-trifluoroacetophenone is a high-value fluorinated aromatic compound characterized by its unique combination of chloro and trifluoromethyl functional groups.
This pale yellow to colorless liquid, with a molecular weight of 261.53 g/mol, serves as a critical intermediate in advanced organic synthesis. The strategic placement of electron-withdrawing groups on the phenyl ring enhances its reactivity in nucleophilic substitution and cross-coupling reactions, making it indispensable for pharmaceutical and agrochemical manufacturing.
Key Features and Applications
In the pharmaceutical sector, this compound acts as a key precursor for synthesizing trifluoromethyl-containing drug candidates, particularly kinase inhibitors and antiviral agents. The trifluoromethyl group improves metabolic stability and membrane permeability of resulting molecules, addressing key challenges in drug development.
Agrochemical manufacturers utilize it to construct next-generation pesticides and herbicides, where the chlorine atoms enable selective biological activity.
Material scientists employ it to develop liquid crystal compounds for display technologies, leveraging its rigid aromatic core and fluorine-induced polarity.
Recent studies also explore its potential in creating specialty polymers with enhanced thermal and chemical resistance for extreme environment applications.https://www.chemicalbook.com/ProductChemicalPropertiesCB0206550.htm
Why Choose Hainan Sincere Industries?
Hainan Sincere Industries stands out as a trusted supplier of 3′,5′-Dichloro-2,2,2-trifluoroacetophenone through its commitment to excellence. The company operates GMP-compliant facilities equipped with advanced fluorination reactors capable of delivering batches with ≥99% HPLC purity. Rigorous quality control protocols include GC-MS and NMR verification to ensure trace metal content below 10 ppm, meeting stringent pharmaceutical standards.
With a dedicated R&D team, Hainan Sincere offers custom synthesis services to modify purity, particle size, or even develop derivative compounds tailored to specific reaction requirements. Their global logistics network ensures reliable cold-chain transportation to maintain product integrity worldwide.
Packaging and Storage
Proper handling begins with optimized packaging: 5 kg double-layer polyethylene bags inside moisture-proof fiber drums for standard orders, though customer-specified packaging. For bulk quantities, nitrogen-inerted stainless steel containers are recommended to prevent clumping and oxidative degradation during long-term storage.
Conclusion
3′,5′-Dichloro-2,2,2-trifluoroacetophenone represents a prime example of how strategically fluorinated aromatics enable breakthroughs across multiple high-tech industries. Its balanced reactivity profile bridges the gap between small-scale laboratory use and industrial production needs.
Hainan Sincere Industries’ technical expertise and quality-focused production make it an ideal partner for organizations seeking reliable access to this specialty chemical. Future applications may emerge in battery electrolytes or catalytic systems, further expanding its already diverse utility.
