N-Acetylmorpholine | 1696-20-4 | C6H11NO2
What is N-Acetylmorpholine?
N-Acetylmorpholine (CAS 1696-20-4) is an organic compound with both amide and cyclic amine functional groups. This colorless liquid possesses a characteristic amine-like odor and demonstrates excellent solubility in both water and most organic solvents.
Chemically classified as a morpholine derivative, its molecular structure combines a six-membered morpholine ring with an acetyl group, creating unique properties that make it valuable for industrial applications.
Applications of N-Acetylmorpholine
In the pharmaceutical sector, it acts as a crucial intermediate in synthesizing various active pharmaceutical ingredients, particularly those requiring morpholine ring structures. The chemical industry utilizes it as a high-boiling polar solvent for reactions requiring elevated temperatures, where its thermal stability proves advantageous.
Additionally, it finds application in polymer production as a catalyst or co-monomer, especially in polyurethane formulations.
The agrochemical sector employs N-Acetylmorpholine in developing certain pesticides and herbicides, where its structural properties enhance product performance.
Recent research has also explored its potential in specialty chemical synthesis and as a corrosion inhibitor in specific industrial systems.
Packaging and Storage
The chemical is typically supplied in polyethylene or stainless steel containers ranging from 180 kg drums to bulk quantities, depending on customer requirements. Storage areas should maintain cool, dry conditions with adequate ventilation, ideally below 25°C to prevent degradation.

Safety and Handling Considerations
While N-Acetylmorpholine is not classified as highly toxic, appropriate safety measures should be observed during handling. The compound can cause mild skin and eye irritation upon direct contact, necessitating the use of personal protective equipment including gloves and safety goggles.
Adequate ventilation should be maintained in working areas to prevent vapor accumulation, and smoking or open flames must be prohibited near storage or handling locations.https://www.chemicalbook.com/ProductChemicalPropertiesCB1713105.htm
Conclusion
N-Acetylmorpholine represents a valuable chemical intermediate with diverse industrial applications, from pharmaceutical synthesis to specialized solvent uses. Proper understanding of its handling requirements and safety profile enables users to maximize its benefits while maintaining safe working environments.
